NF-κB is a ubiquitously expressed transcrIption factor that is normally sequestered by inhibitory proteins IκBs in the cytoplasm. NF-κB is activated by divergent stimuli, such as microbial pathogens, carcinogens and tumor promoters. Activated NF-κB regulates the expression of a large number of genes, including those involved in innate and adaptive immune responses, inflammatory responses, cellular transformation and proliferation. De-regulation of NF-κB is involved in a wide range of human diseases, such as immune deficiency, rheumatoid arthritis and cancer. We take cellular and molecular approaches to identify signaling proteins and regulatory proteins that critically involved in NF-κB activation pathways. We hope to contribute to understanding of the signaling mechanisms and may also suggest new targets for drugs development

Laboratory Introduction