教育经历:

2001 - 2006 , 理学博士 , 生物化学与分子生物学 , 北京大学
1997 - 2001 , 理学学士 , 生物化学与分子生物学 , 北京大学

工作经历:

2019.02 - 今　　 教授 beat365官方网站
2018.02 - 2019.01 长聘副教授 beat365官方网站
2012.01 - 2018.01 助理教授 beat365官方网站
2012.01－今　　研究员 北大清华生命科学联合中心
2006.09－2011.12 博士后 美国梅奥医学院癌症中心（Mayo Clinic Cancer Center）

荣誉奖励:

2018 入选“北京高校卓越青年科学家”计划
2017 教育部青年科学奖
2017 国家杰出青年科学基金
2016 北京大学青年教师教学基本功比赛 理工科 二等奖
2015 郑昌学教学优秀奖
2014 拜耳学者奖
2013 国家优秀青年科学基金
2009 Mayo Clinic“Kendall-Mayo 奖学金”

执教课程:

分子生物学（本，主讲）
表观遗传学基础（本，主讲）
综合实验课（III）(本）
CLS生物化学与分子生物学模块（研）
现代生物学实验技术原理及其应用(研）

      　　 表观遗传信息的继承是生命个体正常发育的基础，在生殖、发育和衰老等过程中发挥关键作用。该过程的失调与多种疾病相关，包括肿瘤、神经退行性病变和早衰等，因而对人类健康产生深远的影响。表观遗传信息的继承的核心阶段发生在细胞周期的S期中的DNA复制过程。伴随DNA复制，母链染色质需要解组装，而在子链上需要重建染色质，意味着母链表观遗传信息在子链间的分配和继承，子代细胞可弹性继承亲本细胞的可遗传的表观遗传信息。
　 本实验室长期致力于表观遗传信息继承（Epigenetic Inheritance）的分子机制。我们以芽殖酵母和胚胎干细胞为研究模式，运用经典的生物化学、遗传学等方法结合前沿的组学方法、荧光成像等技术，以染色质复制过程为切入点，揭示表观遗传信息继承的基本规律，解析其与基因组稳定性维持，细胞命运决定等的关联机理。主要研究内容包括：
　　 1.染色质携带的表观遗传信息的继承和分配机制：重点关注“新、旧”组蛋白在DNA复制叉两条子链的传递机制，阐明该过程对异染色质的建立和维持的影响，探讨其在胚胎发育中的重要作用。
　　 2.染色质组装机器(包括组蛋白分子伴侣、染色质重塑因子和染色质修饰酶等调节因子)和DNA复制机器（复制体）的“对话”机制：DNA复制和染色质复制偶联是生命科学的基础问题之一，这是维持基因组稳定和表观遗传组稳定的核心基础，因此我们长期关注这两个基本过程的偶联机制，重点关注染色质组装对DNA复制反馈的调节机制，以及此过程异常和人类疾病的关系。

Leng, H.#, Liu, S.F.#, Lei, Y., Tang, Y.T., Gu, S.J., Hu, J.Z., Chen, S., Feng, J.X.* and Li, Q*. (2021) FACT interacts with Set3 HDAC and fine-tunes GAL1 transcription in response to environmental stimulation. Nucleic Acids Research, gkab312, https://doi.org/10.1093/nar/gkab312

Xu, Z.Y., Feng, J.X*. and Li, Q* . (2020) Measuring Genome-Wide Nascent Nucleosome Assembly Using Replication-intermediate nucleosome mapping (ReIN-Map). Methods Molecular Biology (Book) Vol.2196. Chapter 10, 978-1-0716-0867-8.

Zhang, W.S., Feng J.X.*, and Li, Q.* (2020) The replisome guides nucleosome assembly during DNA replication. Cell & bioscience. 10.1186/s13578-020-00398-z.

Li, S.Q#., Dong, Z.Q#., Yang, S.S., Feng, J.X., and Li, Q*. (2019) Chaperoning RPA during DNA metabolism. Current Genetics doi: 10.1007/s00294-019-00945-3

Li, Q*., Zhang, X., and Zhang, Z.* (2018). CHAF1B overexpression: A brake for the differentiation of leukemia cells. Cancer Cell 34:693-694.

Li, S.Q#, Xu, Z.Y. #, Xu, J.W. #, Zuo, L.Y., Yu, C.H., Zheng, P., Gan, H.Y., Wang, X.Z., Li, L.T., Sharma, S., Chabes, A., Li, D., Wang, S., Zheng, S.H., Li, J.B., Chen, X.F., Sun, Y.J., Xu, D.Y., Han, J.H., Chan, K.M., Qi, Z., Feng, J.X.*, and Li, Q.* (2018) Rtt105 functions as a chaperone for replication protein A to preserve genome stability The EMBO Journal e99154.(Article recommended by F1000)

Yan, X.W#., Yang, J.Y#., Xu, J.W#., Feng, J.X*., and Li, Q.* (2018). Histone chaperone Spt16p is required for heterochromatin mediated silencing in budding yeast. Protein & Cell 9:652-658.

Liu, S.F.#, Xu, Z.Y. #, Leng, H. #, Zheng, P., Yang, J.Y., Chen, K.F., Feng, J.X., Li, Q. * (2017). RPA binds histone H3-H4 and functions in DNA replication-coupled nucleosome assembly. Science 355, 415-420.

Feng, J.X.＃, Gan, H.Y.＃, Eaton, M.L., Zhou, H., Li, S.Q., Belsky, J.A., MacAlpine, D.M., Zhang, Z.G.* and Li, Q.* (2016). Noncoding transcription is a driving force for nucleosome instability in spt16 mutant cells. Molecular and Cellular Biology 36, 1856-1867. Article of significant interest selected as a Spotlight.

Yang, J.Y.＃, Zhang, X.＃, Feng, J.X.＃, Leng, H., Li, S.Q., Xiao, J.X., Liu, S.F., Xu, Z.Y., Xu, J.W., Li, D., Wang, Z.S., Wang, J.Y., and Li, Q.* (2016). The Histone Chaperone FACT Contributes to DNA Replication-Coupled Nucleosome Assembly. Cell Reports 14, 1128-1141.

Su, D.#, Hu, Q.#, Li, Q.#, Thompson, J.R., Cui, G.F., Fazly, A., Davies, B.A., Botuyan, M.V., Zhang, Z.G.* and Mer, G.* (2012). Structural basis for recognition of H3K56-acetylated histone H3–H4 by the chaperone Rtt106. Nature 483, 104-107 (# Co-first author).

Li, Q.＃, Burgess, R.＃, and Zhang, Z.G.* (2012). All roads lead to chromatin: Multiple pathways for histone deposition. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1819, 238-46 (# Co-first author).

Li, Q., and Zhang, Z.G.* (2012). Linking DNA replication to heterochromatin silencing and epigenetic inheritance. Acta Biochimica et Biophysica Sinica (ABBS) 44, 3-13. This review was selected as the cover story.

Fazly, A., Li, Q., Hu, Q., Mer, G., Horazdovsky, B. and Zhang, Z.G.* (2012). Histone chaperone Rtt106 promotes nucleosome formation using (H3-H4)2 tetramers. The Journal of Biological Chemistry 2287, 10753-10760.

Li, Q., Fazly, A., Zhou, H., Huang, H.S., Zhang, Z.G.* and Stillman, B.* (2009). The Elongator complex interacts with PCNA and modulates transcriptional silencing and sensitivity to DNA damage agents. PLoS Genetics 5, e1000684.

Li, Q.＃, Zhou, H.＃, Wurtele, H., Davies, B., Horazdovasky, B., Verreault, A.* and Zhang, Z.G.* (2008). Acetylation of Histone H3 lysine 56 regulates CAF-1 dependent nucleosome assembly. Cell 134,244-255 (# Co-first author). Previewed in the same issue. Highlighted in Nature Reviews Molecular Cell Biology, September 2008

李晴实验室