本实验室主要兴趣在于：
　　细胞骨架的结构与功能
　　神经系统的发育及细胞分化
　　细胞内膜系统

1. Peiyuan Chai, Yiru Cheng, Chuyi Hou, Lei Yin, Donghui Zhang, Yingchun Hu, Qingzhou Chen, Pengli Zheng, Junlin Teng and Jianguo Chen. USP19 promotes hypoxia-induced mitochondrial division via FUNDC1 at ER-mitochondria contact sites. J. Cell Biol. https://doi.org/10.1083/jcb.202010006
2. Tian Xiaoyu, Teng Junlin and Chen Jianguo. New insights regarding SNARE proteins in autophagosome-lysosome fusion. Autophagy, 1-9. DOI:10.1080/15548627.2020.1823124. 2020. Sep., 24.
3. Tian Xiaoyu, Pengli Zheng, Chenqian Zhou, Xurui Wang, Hua Ma, Wei Ma, Xiaokai Zhou Junlin Teng & Jianguo Chen. DIPK2A Promotes STX17 and VAMP7-mediated Autophagosome-lysosome Fusion by Binding to VAMP7B. Autophagy. 2020, 16:797-810. https://www.tandfonline.com/doi/pdf/10.1080/15548627.2019.1637199?needAccess=true
4. Shen Birong, Pengli Zheng, Nannan Qian, Qingzhou Chen, Xin zhou, Junjie Hu, Jianguo Chen and Junlin Teng. Calumenin-1 Interacts with Climp63 to Cooperatively Determine the Luminal Width and Distribution of Endoplasmic Reticulum Sheets. iScience. 2019. https://doi.org/10.1016/j.isci.2019.10.067
5. Wang Tianning, Yuhong Zou, Ning Huang, Junlin Teng, and Jianguo Chen. CCDC84 acetylation oscillation regulates centrosome duplication by modulating HsSAS-6 degradation. Cell Reports. 2019. 29: 2078-2091
6. Zhou H, Zheng T, Wang T, Li Q, Wang F, Liang X, Chen J* & Teng J*. CCDC74A/B are K-fiber crosslinkers required for chromosomal alignment. BMC Biol. 2019. https://doi.org/10.1186/s12915-019-0694-9.
7. Chen Qingzhou, Junlin Teng & Jianguo Chen. ATL3, a cargo receptor for reticulophagy. Autophagy. 2019. 15(8):1465-1466. DOI:10.1080/15548627.2019.1609862. (Commentary)
8. Chen Qingzhou, Ya Xiao, Peiyuan Chai, Pengli Zheng, Junlin Teng and Jianguo Chen. ATL3 Is a Tubular ER-Phagy Receptor for GABARAP-Mediated Selective Autophagy. Current Biology. 2019. 29（5）：846-855.
9. Yuqing Xia, Ning Huang, Zhiquan Chen, Fangyuan Li, Guiliang Fan, Dandan Ma, Jianguo Chen* & Junlin Teng*. CCDC102B functions in centrosome linker assembly and centrosome cohesion. Journal of Cell Science. 2018. 131, jcs222901. doi:10.1242/jcs.222901.
10. Huang Ning, Donghui Zhang, Song Wang, Junlin Teng & Jianguo Chen. M-Phase Phosphoprotein 9 regulates ciliogenesis by modulating the localization of CP110-CEP97 complex at the mother centriole. Nature Communications. 2018. 9:4511. DOI: 10.1038/s41467-018-06990-9.
11. Zheng Pengli, qingzhou chen, Xiaoyu Tian, nannan qian, peiyuan chai, bing liu, Junjie Hu, Craig Blackstone, Desheng Zhu, Junlin Teng & Jianguo Chen. DNA Damage Triggers Tubular Endoplasmic Reticulum Extension to Promote Apoptosis by Facilitating ER-mitochondria Signaling. Cell Research. 2018. 28:833–854; https://doi.org/10.1038/ s41422-018-0065-z.
RESEARCH HIGHLIGHT: Bock FJ, Tait SWG. p53 REEPs to sow ER-mitochondrial contacts. Cell Res. 2018. 28(9):877-878. doi: 10.1038/s41422-018-0073-z.
12. Huang Ning, Yuqing Xia, Donghui Zhang, Song Wang, Yitian Bao, Runsheng He, Junlin Teng & Jianguo Chen. Hierarchical assembly of centriole subdistal appendages via centrosome binding proteins CCDC120 and CCDC68. Nature Communications. 2017. 8:15057. DOI: 10.1038/ncomms15057.
13. Xu S, Y Xu, L Chen, Q Fang, S Song, J Chen and J Teng. RCN1 suppresses ER stress-induced apoptosis via calcium homeostasis and PERK–CHOP signaling. Oncogenesis. 2017. doi:10.1038/oncsis.
14. Yiding Li, Jiamin Xu, Yafeng Liu, Jia Zhu, Nan Liu, Wenbo Zeng, Ning Huang, Malte J Rasch, Haifei Jiang, Xiang Gu, Xiang Li, Minhua Luo, Chengyu Li, Junlin Teng, Jianguo Chen, Shaoqun Zeng, Longnian Lin, Xiaohui Zhang.. A distinct entorhinal cortex to hippocampal CA1 direct circuit for olfactory associative learning. Nature Neuroscience. 2017, 20 (4), 559-570. doi:10.1038/nn.4517
15. Zhou Haining, Tianning Wang, Tao Zheng, Junlin Teng, Jianguo Chen. Cep57 is a Mis12-interacting kinetochore protein involved in kinetochore targeting of Mad1-Mad2. Nature Communications，2016. doi:10.1038/ncomms10151.
16. Chen Liang, Sizheng Xu, Yiwei Xu,Weiwei Lu, Lin Liu, Di Yue, Junlin Teng & Jianguo Chen， Cab45S Promotes Cell Proliferation throughSERCA2b Inhibition and Ca2+ Signaling， Oncogene. 2016，35: 35-46.
17. Lv Kaosheng, Liang Chen, Yuanjun Li, Pengli Zheng, Yingying Liu, Zenglong Li, Jianguo Chen, and Junlin Teng, Trip6 Promotes Dendritic Morphogenesis through Dephosphorylated GRIP1-dependent Myosin VI and F-actin Organization, J. Neurosci.，2015. 35(6):2559-2571.
18. Chen L, Xu S, Liu L, Wen X, Xu Y, Chen J* and Teng J*, Cab45S inhibits the ER stress-induced IRE1-JNK pathway and apoptosis via GRP78/BiP, Cell Death Dis. 2014. 5：e1219.
19. Mengping Wei, Jian Zhang, Moye Jia, Chaojuan Yang, Yunlong Pan, Shuaiqi Li, Yiwen Luo, Junyuan Zheng, Jianguo Ji, Jianguo Chen, Xinli Hu, Jingwei Xiong, Yun Shi, Chen Zhang. α/β-Hydrolase domain-containing 6 (ABHD6) negatively regulates the surface delivery and synaptic function of AMPA receptors. Proceedings of the National Academy of Sciences. 2016, 113 (19) E2695-E2704. https://doi.org/10.1073/pnas.1524589113
20. Zheng Pengli, Qiao Wang, Junlin Teng, Jianguo Chen*. Calumenin and fibulin-1 on tumor metastasis: Implications for pharmacology. Pharmacological Research. 2015. 99:11-15. Invited Review.
21. Lv Kaosheng(吕考升), Liang Chen, Yuanjun Li, Pengli Zheng, Yingying Liu, Zenglong Li, Jianguo Chen, and Junlin Teng. Trip6 Promotes Dendritic Morphogenesis through Dephosphorylated GRIP1-dependent Myosin VI and F-actin Organization. J. Neuroscience. 2015. 35(6):2559-2571.
22. Qiao Wang, Birong Shen, Liang Chen, Pengli Zheng, Hui Feng, Qingsong Hao, Lin Liu, Xiao Liu, Sizheng Xu, Jianguo Chen*, and Junlin Teng*, Extracellular Calumenin Suppresses ERK1/2 Signaling and Cell Migration by Protecting Fibulin-1 from MMP-13-mediated Proteolysis, Oncogene, 2014, doi: 10.1038/onc.2014.52.
23. Wang Jingjing, Shan Chunyan, Cao Wenyuan, Zhang Chen, Teng Junlin, Chen Jianguo, SCG10 promotes non-amyloidogenic processing of amyloid precursor protein by facilitating its trafficking to the cell surface, Human Molecular Genetics, 2013, 22(24): 4888-4900.
24. Chen L, S Xu, L Liu, X Wen, Y Xu, J Chen*, and J Teng*, 2014. Cab45S inhibits the ER stress-induced IRE1-JNK pathway and apoptosis via GRP78/BiP. Citation: Cell Death and Disease. 2014. 5, e1219; doi:10.1038/cddis.2014.193.
25. Feng Hui, Liang chen, Qiao Wang, Birong Shen, Lin Liu, Pengli Zheng, Sizheng Xu, Xiao Liu, and Jianguo Chen, Junlin Teng, Calumenin-15 Facilitates Filopodia Formation by Promoting TGF-β Superfamily Cytokine GDF-15 TranscrIption, Cell Death and Disease, 2013, 4, e870; doi:10.1038/cddis.2013.403.
26. Wang Qiao, Shen Birong, Zheng Pengli, Feng Hui, Guo Yige, Cao Wenyuan, Chen Liang, Liu Xiao, Zhao Guodong, Xu Sizheng, Shen Weide, Chen Jianguo, Teng Junlin. BmCREC Is an Endoplasmic Reticulum (ER) Resident Protein and Required for ER/Golgi Morphology. JBC. 2013. 288(37): 26649-26657.
27. He Runsheng, Huang Ning, Bao Yitian, Zhou Haining, Teng Junlin, Chen Jianguo. LRRC45, A Novel Centrosome Linker Component, Is Required for Centrosome Cohesion. Cell Reports , 2013. 4: 1100-1107.
28. Wang Jingjing, Shan Chunyan, Cao Wenyuan, Zhang Chen, Teng Junlin*, Chen Jianguo*. SCG10 promotes non-amyloidogenic processing of amyloid precursor protein by facilitating its anterograde trafficking. Hum. Mol. Genet. 2013. 22(24): 4888-4900.
29. He Runsheng, Wu Qixi, Zhou Haining, Huang Ning, Chen Jianguo*, Teng Junlin*. Cep57 Protein Is Required for Cytokinesis by Facilitating Central Spindle Microtubule Organization. J. Biol. Chem. 2013. 288(20): 14384-14390.
30. Miao Linqing, Teng Junling , Lin Jiqiang, Liao Xianzhi, and Chen Jianguo. 14-3-3 protein interact with neurofilament protein-L and regulate dynamic assembly of neurofilament. J Cell Sci. 2013. 126:427-436.
31. Liu Yingying, Lv Kaosheng, Li Zenglong, Yu CH Albert, Chen Jianguo and Teng Junlin. Pacsin1, a tau –interacting protein, regulates axonal elongation and branching by facilitating microtubule instability. J Biol. Chem. 2012. 287(47):39911-39924.
32. Wu Qixi, He Runsheng, Zhou Haining, Yu CH Albert, Zhang Bo, Teng Junlin and Chen Jianguo， Cep57, a NEDD1-binding pericentriolar material component, is essential for spindle pole integrity , Cell Res , 2012. 22（9）：1390-1401.
33. Wang Qiao, Teng Junlin, Shen Birong, Zhang Wei, Guo Yige, Su Xiaolei，Zhang Chuanxi, Yu Albert CH, Chen Jianguo. Characterization of Kinesin-like Proteins in Silkworm Posterior Silkgland Cells, Cell Res. 2010. 20: 713-727.
34. Dong Yan, Hua Dong Liu, Rui Zhao, Chun Zhang Yang, Xiao Qian Chen, Xin HongWang, Lok Ting Lau, Jianguo Chen and Albert Cheung Hoi Yu. Ischemia activates JNK/c-Jun/AP-1 pathway to up-regulate 14-3-3gamma in astrocyte. J Neurochem. 2009. 109 (Suppl. 1) :182–188.
35. Li Huihui, Yan Guo, Junlin Teng, Mingxiao Ding, Albert Cheung Hoi Yu and Jianguo Chen. 14-3-3gamma affects dynamics and integrity of glial filaments by binding to phosphorylated GFAP. J of Cell Science. 2006. 119: 4452-4461
36. Chengrong Lu, Yong Li, Yanlin Zhao, Guichun Xing, Fei Tang, Qingming Wang,Yuhui Sun, Handong Wei, Xiaoming Yang, Chutse Wu, Jianguo Chen, Kun-liang Guan, Chenggang Zhang, Huipeng Chen, Fuchu He. Intracrine hepatopoietin potentiates AP-1 activity through JAB1 independent of MAPK pathway. The FASEB J. 2002, 16: 90-92
37. Junlin Teng, Yosuke Takei, Akihiro Harada, Takao Nakata, Jianguo Chen and Nobutaka Hirokawa. Synergistic effects of MAP2 and MAP1B knockout in neuronal migration, dendritic outgrowth, and microtubule organization. J. Cell Biology. 2001. 155(1):65-76.
38. Sang huaceng, Zhonghua Lu, Yulong Li, Binggen Ru, Wenqing Wang, and Jianguo Chen. Phosphorylation of tau by glycogen synthase kinase 3beta in intact mammalian cells influences the stability of microtubules. Neuroscience Leter. 2001. 312:141-144.
39. Chen, J., Nakata, T., Zhang, Z. and Hirokawa, N. The C-terminal tail domain of neurofilament protein-H (NF-H) forms the crossbridges and regulates neurofilament bundle formation. Journal of Cell Science. 2000. 113, 3861-3869.
40. Terunaga Nakagawa, Jianguo Chen, Zhizeng Zhang, Yoshimitsu Kanai, and Nobutaka Hirokawa. Two Distinct Function of the Carboxyl-terminal Tail Domain of NF-M upon Neurofilament Assembly: Cross-bridge Formation and Longitudinal Elongation of Filaments. J. Cell Biol. 1995. 129:411-429.
41. Kanai, Y., Chen, J. and Hirokawa, N. Microtubule bundling by tau proteins in vivo: analysis of functional domains. EMBO J. 1992. 11: 3953 - 3961.
42. Chen, J., Kanai, Y., Cowan, N. J. and Hirokawa, N. Projection domains of MAP2 and tau determine spacings between microtubules in dendrites and axons. Nature. 1992. 360: 674 - 677.

我们致力于细胞增殖、分化，以及个体发育过程中细胞结构与功能的动态变化及其调控机制等方面的研究。特别关注细胞骨架对细胞极性化形态结构以及生命活动过程的组织作用；神经系统的发育与细胞分化；细胞内膜系统的动态行为与信号转导、肿瘤细胞的增殖、细胞自噬和细胞凋亡等的关系。