During endoplasmic reticulum (ER) stress, homeostatic signaling through the unfolded protein response (UPR) augments ER protein-folding capacity. If homeostasis is not restored, the UPR triggers apoptosis. We found that the ER transmembrane kinase/endoribonuclease This talk will. is a key component of this apoptotic switch.(RNase) Ire1α introduce to you our effort on trying to reveal the mechanism of this switch and provide therapeutic insights into the manipulation of this switch for treating diseases.

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