Dr. Hang He published a paper in Nature Genetics with his collaborator.
Since the development of single-hybrid maize breeding programs in the first half of the twentieth century, maize yields have increased over sevenfold, and much of that increase can be attributed to tolerance of increased planting density. To explore the genomic basis underlying the dramatic yield increase in maize, we conducted a comprehensive analysis of the genomic and phenotypic changes associated with modern maize breeding through chronological sampling of 350 elite inbred lines representing multiple eras of germplasm from both China and the United States. We document several convergent phenotypic changes in both countries. Using genome-wide association and selection scan methods, we identify 160 loci underlying adaptive agronomic phenotypes and more than 1,800 genomic regions representing the targets of selection during modern breeding. This work demonstrates the use of the breeding-era approach for identifying breeding signatures and lays the foundation for future genomics-enabled maize breeding.
Original link: https://www.nature.com/articles/s41588-020-0616-3
