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Detection of Colorectal Cancer in Circulating Cell-Free DNA by Methylated CpG Tandem Amplification and Sequencing

Apr.25,2019

Dr. Lu Wen published a paper on Clinical Chemistry with his collaborator.


Aberrant DNA hypermethylation of CpG islands occurs frequently throughout the genome in human colorectal cancer (CRC). A genome-wide DNA hypermethylation analysis technique using circulating cell-free DNA (cfDNA) is attractive for the noninvasive early detection of CRC and discrimination between CRC and other cancer types.


Original link: http://clinchem.aaccjnls.org/content/early/2019/04/19/clinchem.2019.301804