Prof. Shiqiang Qiang published a paper on Circulation Research.
β2AR stimulation compartmentalizes β1AR signaling into nanoscale local domains in a phosphodiesterase-4-dependent manner by targeting the C-terminus of β1ARs. This finding reveals a fundamental "negative feed-forward" mechanism that serves to avoid the cytotoxicity of circulating catecholamine and to sharpen the transient β1AR response of sympathetic excitation.
Original link: https://www.ahajournals.org/doi/abs/10.1161/CIRCRESAHA.118.314322
