Structures and mechanisms of macromolecular complexes involved in DNA processing

Research Seminar
Title: Structures and mechanisms of macromolecular complexes involved in DNA processing
Speaker: Xiaodong Zhang, Ph.D.
Professor,
Department of Medicine,
Imperial College London
Time: 13:00-14:30, Nov. 3, 2017
Location: Youcai Deng Hall，School of Life Sciences（生科院邓祐才报告厅）
Host：Xiaodong Su
Abstract：
Almost all activities inside our cells are carried out by macromolecular complexes. Defects in these protein and complexes can cause malfunction and diseases. My research focuses on elucidating the structures and mechanisms of large macromolecular complexes, especially those involved in DNA processing, such as transcription regulation and DNA damage response, by combining biochemistry, X-ray crystallography and electron microscopy techniques. I will discuss our work on understanding the mechanisms of transcription regulation, especially how the initial DNA opening occurs during transcription initiation. I will also discuss our recent progress on elucidating structures and mechanisms of protein complexes involved in chromatin remodelling, DNA damage signalling and repair.
Welcome！